Targeted Temperature Management Guideline - LGI PICU
|Next review: 26/09/2025|
|Approved By: Trust Clinical Guidelines Group|
|Copyright© Leeds Teaching Hospitals NHS Trust 2022|
This Clinical Guideline is intended for use by healthcare professionals within Leeds unless otherwise stated.
LGI PICU Targeted Temperature Management Guideline
- Why do we cool patients?
- What does the current literature say about cooling? - THAPCA trail results
- Which patients SHOULD be considered for cooling?
- Which patients SHOULD NOT be cooled (exclusion criteria)?
- What temperature should the patient be cooled to and for how long?
- When should the patient be cooled?
- How should the patient be cooled?
- What parameters should be monitored during cooling?
- What are the adverse effects of cooling?
- What about Re- warming?
- Flow chart
- Two neonatal and one paediatric trial as well as some adult clinical trials have shown improved outcomes in patients who have been cooled following hypoxic-ischaemic or cardiac (ventricular fibrillation) arrest events2,3,5,6
- There is also historic evidence from cold water drowning and deep hypothermic circulatory arrest used in cardiac surgery, demonstrating neurologically intact survival in spite of prolonged periods of cardiac arrest
- Current resuscitation guidelines recommend cooling following cardiac arrest in children
- Cooling reduces metabolic demand and oxygen consumption and preserves organ function
- Cooling also has other uses, for example: treating Low Cardiac Output State (LCOS) and Junctional Ectopic Tachycardia (JET) and Hyperpyrexia
- There is equipoise in the literature regarding the benefits of cooling post cardiac arrest as the more recent clinical trials in adults have demonstrated longer hospital stays without improvement in outcome2
- The evidence from neonatal hypoxic ischaemic encephalopathy trials demonstrate improved survival and neurological outcome with cooling3
- The THAPCA (Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children) trial which was published in May 2015 showed no significant difference in the outcomes of children treated with therapeutic hypothermia following cardiac arrest compared to normothermia1.
- HAPCA Results:
A total of 295 patients underwent randomization. Among the 260 patients with data that could be evaluated and who had a Vineland Adaptive Behavior Scales, second edition (VABS-II) score of at least 70 before cardiac arrest, there was no significant difference in the primary outcome between the hypothermia group and the normothermia group (20% vs. 12%; relative likelihood, 1.54; 95% confidence interval [CI], 0.86 to 2.76; P=0.14). Among all the patients with data that could be evaluated, the change in the VABS-II score from baseline to 12 months was not significantly different (P=0.13) and 1-year survival was similar (38% in the hypothermia group vs. 29% in the normothermia group; relative likelihood, 1.29; 95% CI, 0.93 to 1.79; P=0.13). The groups had similar incidences of infection and serious arrhythmias, as well as similar use of blood products and 28-day mortality.
- There are however a number of considerations regarding the trial:
- The trial population was a small sample size
- Both groups were cooled i.e.. the study group was cooled to hypothermia and the control group was cooled to normothermia.
- The confidence intervals are wide
- The raw data shows a trend towards improved survival and neurological outcome in the hypothermia group
The Paediatric Traumatic Brain Injury Consortium: Hypothermia (the Cool Kids Trial), published in 2013 showed hypothermia for 48 hours followed by slow rewarming did not reduce mortality following paediatric severe traumatic brain injury8.
- The Cool Kids Trial8:
- This was a multinational, phase 3 RCT at 15 centres assessing the effect on mortality of moderate hypothermia (32-33°C) with slow rewarming compared with normothermia after paediatric severe traumatic brain injury (randomised 1:1).
- 77 patients were randomized. Interim data analysis did not identify any difference in mortality (6 [15%] of 39 patients in hypothermia group and 2 [5%] of 38 patients in normothermia group; p=0.15) and also no difference in global function three months after the injury (poor outcome in Glasgow outcome score in 47% of hypothermia group and 51% of normothermia group). There was no difference in adverse events between groups.
- The planned sample size was 340 patients. The trial was stopped early due to futility based on the results of interim analysis8.
- Similarly, this trial had a small sample size. The study also recognized that there was difference between centres in the stepwise management of raised ICP which may have affected overall results.
- Paediatric patients up to the age of 16 years who have suffered a cardiac arrest of longer than 5 minutes duration and remain unconscious post resuscitation
- Patients who are being resuscitated on to extracorporeal support (ECMO)
- Post-arrest patients who do not meet the exclusion criteria
- Cardiac patients at risk of or with Low Cardiac Output State (LCOS) and Junctional ectopic tachycardia (JET) (See Junctional Ectopic Tachycardia Guideline)
- Patients in Low Cardiac Output State and needing more than one inotrope
- Patients with refractory tachyarrhythmias
- Patients who have persistent pyrexia of 39°C or more with associated haemodynamic or metabolic instability - cool to 38°C
- Head injury patients with persistent temperature of over 38 degrees (these patients should be cooled to a minimum of 37.0°C)
Decision for active cooling should be made in agreement with the duty Intensivist and documented in medical notes (including target temperature)
- Post-arrest patients who are deemed by the on-duty Intensivist to be irrecoverable (cooling does not stop the patient from dying but may delay death)
- Patients who have active major haemorrhage
- Head injury patients who are NOT pyrexial unless they are being cooled for refractory high Intracranial Pressure (ICP) when other measures have failed
- Septic patients, unless there is hyperpyrexia associated with haemodynamic instability
- Post arrest patients should be cooled to 36 degrees for up to 72 hours (Range: 35.5-36.5°C)
- Cardiac patients should be cooled to 35 degrees for 12 hours unless otherwise specified by the duty Consultant Intensivist (Range 34.5-36°C)
- Head injury patients should only be cooled at Consultant request only and should be cooled to 37 degrees for 24 hours (Range 36.5-37.5°C)
- Septic patients should only be cooled at Consultant request only and they should be cooled to 38 degrees for 24 hours (Range 37.5-38.5°C)
- Post-arrest patients should be cooled as soon as possible after the event, if there are no cooling facilities available, the patient should not be actively re-warmed
- Cardiac (e.g post cardiac surgery), Septic and Neuro (e.g. head injury / refractory status epilepticus) patients should be cooled at the discretion of the duty Intensivist
- Patients who are being resuscitated onto ECMO (Extra Corporeal Membrane Oxygenation) should be rapidly cooled during cannulation (use ice packs on and around the head and intravenous cold sodium chloride 0.9% to achieve this)
- There are 3 phases of cooling: Induction, Maintenance and Re-warming
- The Re-warming phase is the MOST RISKY time for the patient
- Once a decision to cool a patient has been made, the patient should be cooled as rapidly as possible to the desired temperature (see flow diagram)
- Ensure the patient is adequately sedated before cooling commences
- Commence paralysis once the temperature drops below 36°C to prevent shivering
- Patients should be cooled with a cooling blanket or appropriate cooling system
- If a cooling blanket is not available, the patient can be cooled in the first instance with cool packs and the polar air blanket
- If cooling is not adequate, then 5-10ml/kg of cold (refrigerated) intravenous sodium chloride 0.9% can be given over 15-30 minutes to achieve the desired temperature
- Gastric and bladder washouts with cold sodium chloride 0.9% infusion fluid can only be used under the supervision of the duty Intensivist (unlicensed use of sodium chloride 0.9% infusion fluid)
- In rare instances Continuous Veno-Venous Hemofilatration Dialysis (CVVHD) can be used to cool patients when other strategies have failed but the benefits must outweigh the risks
- 3 lead ECG monitoring, arterial blood pressure monitoring, core & central temperature monitoring
- Core temperature should be using an appropriately placed oesophageal probe (mid-oesophagus)
- 12 lead ECG is required if heart rate less than 100 in neonates, less than 80 in young children or less than 60 in teenagers
- 4-6 hourly blood gases & 12 hourly central venous gas to assess the central venous oxygen saturations (can be done instead of an arterial gas)
- Usual PICU blood tests according to clinical status (see blood testing on PICU Guide)
- Daily blood cultures for patients cooled longer than 48 hours
- Peripheral perfusion i.e. 6 hourly skin colour and integrity check
- Shivering which results in an increase in metabolic demand
- Bradycardia/ arrhythmias
- Immunosuppression with increased infection risk
- Mild coagulopathy (mild platelet dysfunction and delay in thrombus formation - only relevant in bleeding patients and those cooled below 35°C)7
- Electrolyte disturbances
- Insulin resistance
- Impaired drug clearance
- Cold diuresis and hypovolaemia
- Re-warming is the MOST RISKY TIME for the patient and should be strictly controlled
- Rapid re-warming is associated with haemodynamic instability and adverse neurological outcomes
- Patients should not be actively re-warmed in the first instance; the cooling strategies should be reduced to allow for a gradual rise in core temperature
- Patients should be re-warmed at a rate of NO MORE THAN 0.5°C every 2 hours to a temperature between 36 and 37°C (normothermia)
- Once normothermia is achieved, it should be maintained.
- The patient should not be allowed to overshoot and become pyrexial for at least 12 hours after achieving normothermia
- If the temperature rises above 37°C or is rising faster than 0.5°C every 2 hours, cooling strategies should be re-implemented to bring the temperature back in to the target range
Cooling following cardiac arrest
|Target patient group:||Paediatric patients less than 16 years of age|
|Target professional group(s):||Secondary Care Doctors
Secondary Care Nurses
- Moler FW, Silverstein FS, Holubkov R, et al Therapeutic Hypothermia after Out-of-Hospital Cardiac Arrest in Children. N Engl J Med. 2015 May 14;372(20):1898-908. doi: 10.1056/NEJMoa1411480. Epub 2015 Apr 25.
- Nielsen N, Wetterslev J, Cronberg T, et al Targeted temperature management at 33 degrees Celsius versus 36 degrees Celsius after cardiac arrest N Engl J Med. 2013 Dec 5;369(23):2197-206. doi: 10.1056/NEJMoa1310519. Epub 2013 Nov 17.
- Azzopardi DV, Strohm B, Edwards AD, et al Moderate Hypothermia to Treat Perinatal Asphyxial Encephalopathy . N Engl J Med. 2009 Oct 1;361(14):1349-58. doi: 10.1056/NEJMoa0900854.
- Adelson PD Hypothermia following Pediatric Traumatic Brain Injury J Neurotrauma. 2009 Mar;26(3):429-36. doi: 10.1089/neu.2008.0571.
- Bernard SA1, Gray TW, Buist MD, Treatment of comatose survivors of out-of-hospital cardiac arrest with induced hypothermia N Engl J Med. 2002 Feb 21;346(8):557-63.
- Hypothermia after Cardiac Arrest Study Group. Mild therapeutic hypothermia to improve the neurologic outcome after cardiac arrest. N Engl J Med. 2002 Feb 21;346(8):549-56.
- Polderman KH, Hypothermia and coagulation. Crit Care 2012;16(Suppl 2):A20
- Adelson PD, Wisniewski, SR, Beca J, Brown SD, et al, Comparison of hypothermia and normothermia after severe traumatic brain injury in children (Cool Kids): a phase 3 randomised controlled trial. The Lancet Neurology 2(6):546–553, 2013
Trust Clinical Guidelines Group
LHP version 2.0
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